As insulin resistance worsens to overt type 2 diabetes. Journal preproofs ethanol extract of propolis prevents highfat dietinduced insulin resistance and obesity in association with modulation of gut microbiota in mice weicai, jixiong xu, gang li, tao liu, xiali guo, huajie wang, liping luo pii. High fat diet hfd feeding is a common mode of inducing insulin resistance in rodents that rapidly causes progressive metabolic dysfunction 7,8. However, bone marrow graft experiments indicated that. Aug 31, 2010 a highfat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain francois r.
Eep increased antiobesity and antiinflammatory bacteria and reduced proinflammatory bacteria in hfdfed mice. The root of platycodon grandiflorus pg, with hepatoprotective and antioxidation effects, has a long history of being used as food and herbal medicine in asia. However, it is also a popular edible seaweed and its extracts exerts antiinflammatory and antioxidant effects. Obesity, defined as an excessive accumulation of lipid in fat tissue, is associated with an elevated risk of developing insulin resistance and metabolic abnormalities, including diabetes and cardiovascular disease 1. In this study, we investigated the role of peroxisome proliferatoractivated receptor. Polysaccharide extracted from wuguchong reduces highfat. Emerging evidence suggests that gut microbiota dysbiosis is closely associated with obesity and its related metabolic complications. Protection against high fat diet induced muscle insulin resistance. The intraperitoneal insulin tolerance test was performed in male and female mice after 8 weeks a and b and 12 weeks c and d of hfd feeding.
We fed watanabe heritable hyperlipidemic whhl rabbits with a. Objective the increasing prevalence of obesity and type 2 diabetes t2d demonstrates the failure of conventional treatments to curb these diseases. Diet plays an essential role in preventing insulin resistance. Xy and vst scatterplots show 519 genes red dots that are differentially expressed in tv fat between high and low insulin resistance mice. However, it remains unclear what mechanisms are involved in the antiobesity phenotype and whether gf mice develop insulin resistance and. Sicyos angulatus prevents highfat dietinduced obesity and insulin resistance in mice. Pdf acupuncture targeting sirt1 in the hypothalamic. Germfree c57bl6j mice are resistant to highfatdiet. Ethanol extract from ulva prolifera prevents highfat diet. Barnes, ii, masakuni tokunaga, gabriel martinezsantibanez, lynn geletka, carey n. Baiba attenuates insulin resistance and inflammation. Therefore, we investigated the hypolipidemic effect of a. Sexspecific association between the gut microbiome and high. Jun 03, 2008 the flax seedolive oil diet induces insulin resistance of muscle glucose transport.
Mouse skeletal muscle c2c12 cells and c57bl6j mice were treated with palmitate or a highfat diet hfd. A mouse model of dietinduced obesity and insulin resistance. Sicyos angulatus prevents highfat dietinduced obesity. These tfam effects on muscle are shown to be exerted by.
Highfat dietinduced obesity exacerbates kainic acid. Highfat dietinduced insulin resistance in single skeletal muscle. High fat diet feeding induced insulin resistance exacerbates. We investigated the contributions of berberine and metformin combination to the inhibition of sebocyte apoptosis in high. Buchner, taehwa chun, thrombospondin 1 mediates highfat dietinduced muscle fibrosis and insulin resistance in male mice, endocrinology, volume 154, issue 12, 1 december 20, pages 45484559, s. Clinically, insulin resistance may be manifested by glucose. Highfat diet, muscular lipotoxicity and insulin resistance. Recent studies showed that germfree gf mice are resistant to obesity when consuming a highfat, highcarbohydrate western diet. Protection against highfat dietinduced muscle insulin resistance.
Eating foods with a low gi and gl, as well as managing body weight and abdominal fat can reduce the risk. Jerry olefsky and his colleagues now show that neutrophils are. Pdf high fat diet induced insulin resistance and elevated retinol. Lifestyle evolution, and precisely the spreading of fatenriched diet, largely contributes to the worldwide growing incidence of type 2 diabetes and cardiovascular diseases. In conclusion, the present study shows that a highfat kd causes hepatic insulin resistance in mice, which can be attributed to an increase in hepatic dag content, leading to pkc.
Furthermore, vismodegib, an inhibitor of shh signaling, attenuated erk phosphorylation induced by a highfat diet hfd and restored ppar. Two opposite views are debated on mechanisms by which mitochondrial function could be involved in skeletal muscle ir. Our aim in this study was to address whether dietinduced insulin resistance plays any roles in the development of aortic and coronary atherosclerosis in hyperlipidemic rabbits. Empagliflozin reverses obesity and insulin resistance. Highfat dietinduced insulin resistance in single skeletal muscle fibers is fiber type selective.
However, the tissuespecific function of sirt6 in the adipose tissue remains unknown. Highfat diets cause insulin resistance despite an increase. Insulin resistance mediates high fat diet induced pulmonary fibrosis and airway hyperresponsiveness through the tgf. Sexspecific sensitivity to highfat diet hfdinduced insulin resistance with or without antibiotic pretreatment. We first assessed the effect of hfd on of the expression of cyp4a and levels of 20hete. The gut microbiota has been put forward as a key player in the pathophysiology of diet induced t2d.
However, it remains unclear what mechanisms are involved in the antiobesity phenotype and whether gf mice develop insulin resistance and dyslipidemia with high fat hf feeding. Sexspecific association between the gut microbiome and. Germfree c57bl6j mice are resistant to highfatdietinduced insulin resistance and have altered cholesterol metabolism. These tfam effects on muscle are shown to be exerted by molecular. The experimental model consisted of 3 monthold c57bl6j mice fed either a normal chow diet control group or a hfd 60% of calorie from fat. Obesity is a severe public health threat worldwide. Ji hyun choi 1,2, jungran noh 1, yonghoon kim 1,2, jaehoon kim 1, eunjung kang 1, donghee choi 1, jung hyeon choi 1, jinpyo an 3, wonkeun oh 3, chulho lee 1,2. Diet induced obesity model will result in multiple organ changes when comparing to its control mice. Insulin resistance in heart, adipose tissue, liver, and muscle, adipose tissue hypertrophy and inflammatory cell infiltration, and hyperinsulinemia are robustly. For development of insulin resistance, we fed the male wistar rats with high fat diet hfd for eight weeks, followed by 6hydroxydopamine 6ohda administration, a toxin widely used for pd induction, in medial forebrain bundle mfb of rats. We fed watanabe heritable hyperlipidemic whhl rabbits.
Moreover, this study found that a kd increases energy expenditure, which results in weight loss. Highfat diet hfdinduced obesity is associated with insulin resistance, which may affect brain synaptic plasticity through impairment of insulinsensitive processes underlying neuronal survival, learning, and memory. High fat diet induces brain insulin resistance and cognitive. The main objective of this study was to isolate and identify the betaycanins from hylocereus undatus whitefleshed pitaya peel and evaluate their ability to ameliorate obesity, insulin resistance, and hepatic steatosis in high fat diet hfd induced obese mice. The purified pitaya peel betacyanins ppbns were identified by liquid. These results suggest that hz has a promising pharmacological effect on high fat diet induced obesity, hepatic steatosis and insulin resistance, which may have the potential for clinical application. High fat diet induces central obesity, insulin resistance and microvascular dysfunction. The flax seedolive oil diet induces insulin resistance of muscle glucose transport. The present study investigated the effect of senna alata s. A polyphenolrich cranberry extract protects from diet. We assessed the effect of cga at a physiologically obtainable dose 1 gkg of diet on high fat diet induced obesity, glucose intolerance, insulin resistance, and also fatty acid oxidation and insulin signaling in c57bl6 male mice.
Mar 27, 2019 diet plays an essential role in preventing insulin resistance. Estrogens protect against highfat dietinduced insulin. Helminthostachys zeylanica alleviates hepatic steatosis. However, it is unclear whether obesity affects excitotoxicityinduced neuronal cell death. Sonic hedgehog signaling instigates highfat dietinduced. Neutrophils mediate insulin resistance in mice fed a highfat. Fatspecific sirt6 ablation sensitizes mice to highfat. Thrombospondin 1 mediates highfat dietinduced muscle. Unraveling the temporal pattern of dietinduced insulin resistance. When maintained on a highfat diet hfd, mgat2deficient mice were protected from hfdinduced obesity and insulin resistance. We also observed that in obese patients, the expression of sirt6 expression is reduced, which is associated with a reduction of atgl expression. We assessed the effect of cga at a physiologically obtainable dose 1 gkg of diet on highfatdietinduced obesity, glucose intolerance, insulin resistance, and also fatty acid oxidation and. Nobiletin improves obesity and insulin resistance in high.
Allomyrina dichotoma larva extract ameliorates the hepatic. Highfat diet induces hepatic insulin resistance and impairment of. We show that musclespecific overexpression of human mitochondrial transcription factor a tfam attenuates high fat diet hfd induced fat gain and ir in mice in conjunction with increased energy expenditure and reduced oxidative stress. Supporting its causal role in these pathophysiological processes, highfat feeding was demonstrated in animal models to trigger insulin resistance, one of the major features of the metabolic syndrome 2, 3. Obese mice were fed a hfd for 8 weeks and then treated without hfd control group or with nob at 10 or 100 mgkg. Highfat dietinduced obesity and insulin resistance in. Jun 14, 2012 in oral fat tolerance test oftt, mgat2deficient mice absorbed less fat into the circulation. Euglycemichyperinsulinemic clamps demonstrated a marked protection against highfat dietinduced insulin resistance in cyp2e1 knockout mice, with enhanced adipose tissue glucose uptake and insulin suppression of hepatic glucose output. Jan 20, 2016 it has been suggested that skeletal muscle mitochondria play a key role in high fat hf diet induced insulin resistance ir. Oct 08, 2014 to determine the metabolic effects of grapefruit juice consumption we established a model in which c57bl6 mice drank 2550% sweetened gfj, clarified of larger insoluble particles by centrifugation cgfj, ad libitum as their sole source of liquid or isocaloric and sweetened water. Pdf prevention of high fat diet induced insulin resistance in. Purified betacyanins from hylocereus undatus peel ameliorate.
Highfat diets, insulin resistance and declining cognitive. Frontiers skeletal muscle mitochondrial bioenergetics and. High fat diet induced insulin resistance and glucose. Pancreatic islets will become hypertrophic and then degenerate. Aug 19, 2010 recent studies showed that germfree gf mice are resistant to obesity when consuming a high fat, high carbohydrate western diet. Diet induced insulin resistance ir adversely affects human health and life span. Paradoxically, mice with an inherited deficiency of the mitochondrial fatty acid oxidation enzyme, very longchain acylcoa dehydrogenase vlcad, were protected from highfat dietinduced obesity and liver and muscle insulin resistance. Replacement of the corn oil 18% of total energy in the diet with fish menhaden oil provided significant, but only partial, protection against the muscle insulin resistance induced by 4 wk on the highfat diet fig. Polysaccharide extracted from wuguchong reduces highfat diet. Sea cucumber saponin liposomes ameliorate obesityinduced inflammation and insulin resistance in highfatdietfed mice. Ko would increase insulin signaling and brown fat functionality, conferring resistance to dietinduced obesity and its associated metabolic complications. Importantly, cranberry vaccinium macrocarpon aiton is associated with a number of beneficial health effects. To determine the metabolic effects of grapefruit juice consumption we established a model in which c57bl6 mice drank 2550% sweetened gfj, clarified of larger insoluble particles by centrifugation cgfj, ad libitum as their sole source of liquid or isocaloric and sweetened water.
Neutrophils mediate insulin resistance in mice fed a high. Dietary platycodon grandiflorus attenuates hepatic insulin. In oral fat tolerance test oftt, mgat2deficient mice absorbed less fat into the circulation. Sicyos angulatus prevents highfat dietinduced obesity and. Consumption of high fat diet and sugary drink hfs leads to abnormal metabolic phenotype in mice. However, despite a similar body weight, obese highfat dietfed mice are more insulin resistant than mice fed an isocaloric lowfat diet. The aim of the present study is to investigate the effects of polysaccharide extracted from wuguchong pew on high fat diet hfd induced obesity, and the potential mechanisms involving modulation of the gut.
Replacement of the corn oil 18% of total energy in the diet with fish menhaden oil provided significant, but only partial, protection against the muscle insulin resistance induced by 4 wk on the high fat diet fig. Our aim in this study was to address whether diet induced insulin resistance plays any roles in the development of aortic and coronary atherosclerosis in hyperlipidemic rabbits. Ethanol extract of propolis prevents highfat dietinduced. Resistance to highfat dietinduced obesity and insulin.
Highfat diet impairs insulin signaling in a 20hetedependent manner. Dimethylarginine dimethylaminohydrolase 1 protects against. The 6ohda treatment resulted in neuronal damage and loss of striatal dopamine level. Highfructose and highfat dietinduced insulin resistance enhances. The role of dietary fat in obesityinduced insulin resistance. Here, we evaluated the role and mechanism of shh signaling in obesityassociated insulin resistance and characterized its effect on ppar we showed that shh expression was upregulated in subcutaneous fat from obese mice. Moreover, the insulin sensitivityassociated index, which evaluates insulin function, was also significantly restored. In one theory, mitochondrial dysfunction is suggested to cause intramyocellular lipid accumulation leading to ir. Obesity and insulin resistance affect metabolic reactions, but their ensuing contributions to macrophage metabolism remain insufficiently understood.
Ethanol extract of propolis eep reduced high fat diet hfd induced weight gain, liver fat accumulation, and insulin resistance. The finding that dietinduced insulin resistance in the cyp4a14. Insulin resistance, type 1 and type 2 diabetes, and. Mgat2 deficiency ameliorates highfat dietinduced obesity. Supplementation of a highfat diet with chlorogenic acid. Insulin resistance, type 1 and type 2 diabetes, and related. Sea cucumber saponin liposomes ameliorate obesityinduced. The lardcorn oil diet and other highfat diets induce insulin resistance of muscle glucose transport in rats within a few weeks and, depending on type of fat and genetic background, diabetes in rats 25. The purpose of this study was to investigate the effects of a highfat diet hfd on neuroinflammation and oxidative stress in the hippocampus of kainic acid katreated mice.
Senna alata leaf extract restores insulin sensitivity in high. Gbb signaling provokes insulin resistance by increasing tribbles expression. We show that musclespecific overexpression of human mitochondrial transcription factor a tfam attenuates highfat diet hfdinduced fat gain and ir in mice in conjunction with increased energy expenditure and reduced oxidative stress. Highfat diet hfdinduced obesity is associated with insulin. However, under conditions of elevated plasma fatty acid levels and high dietary fat intake, conditions implicated in the development of modern diseases such as obesity and type 2 diabetes mellitus, fat accumulation in liver and muscle intramyocellular lipids. Highfat diet induces hepatic insulin resistance and.
Infiltration of various immune cell types into the fat tissue and liver has been implicated in obesity induced insulin resistance. In this study, we showed that fatspecific sirt6 knockout fko sensitized mice to highfat dietinduced obesity, which was attributed to adipocyte hypertrophy rather than adipocyte hyperplasia. Osteopontin is required for the early onset of high fat diet. The aim of the present study is to investigate the effects of polysaccharide extracted from wuguchong pew on highfat diet hfdinduced obesity, and the potential mechanisms involving modulation of the gut. In parallel, adipose tissue was protected against highfat dietinduced proinflammatory cytokine production. When maintained on a high fat diet hfd, mgat2deficient mice were protected from hfd induced obesity and insulin resistance. These results suggest that hz has a promising pharmacological effect on highfat dietinduced obesity, hepatic steatosis and insulin resistance, which may have the potential for clinical application. Tianhe li, run feng, chenyang zhao, yue wang, jian wang, shasha liu, jianwei cao, hongyun wang, ting wang, yuting guo, and. The main objective of this study was to isolate and identify the betaycanins from hylocereus undatus whitefleshed pitaya peel and evaluate their ability to ameliorate obesity, insulin resistance, and hepatic steatosis in highfatdiet hfdinduced obese mice. High fat diet hfd induced obesity is associated with insulin resistance, which may affect brain synaptic plasticity through impairment of insulin sensitive processes underlying neuronal survival, learning, and memory. In humans, a high fat diet is the major cause of obesity and insulin resistance. The flax seedolive oil diet also results in decreases in insulin responsiveness of glucose. High fat dietinduced obesity is associated with insulin resistance ir and other chronic.
Highfat diet will lead to hepatic steatosis and fatty liver changes could be obviously observed after dissection. Senna alata leaf extract restores insulin sensitivity in. Frontiers skeletal muscle mitochondrial bioenergetics. Osteopontin is required for the early onset of high fat. Infiltration of various immune cell types into the fat tissue and liver has been implicated in obesityinduced insulin resistance.
Distinct gene signatures predict insulin resistance in. Jan 20, 2020 sexspecific sensitivity to high fat diet hfd induced insulin resistance with or without antibiotic pretreatment. Ulva prolifera is the major causative species in the green tide, a serious marine ecological disaster, which bloomed in the yellow sea and the bohai sea of china. Male icr mice were induced to become obese by being fed a hfd 45 kcal% lard fat for 12 weeks. Imcl is associated with the development of insulin resistance. Allomyrina dichotoma larva is a nutritionalworthy future food resource and it contributes to multiple pharmacological functions. Fatspecific sirt6 ko also increased inflammation in the adipose tissue, which may have contributed to insulin resistance in highfat dietfed fko mice. Individuals with insulin resistance and resulting impaired glucose tolerance along with type 2 diabetes showed an increased prevalence of atherosclerosis.
Sicyos angulatus prevents high fat diet induced obesity and insulin resistance in mice. Highfat feeding caused insulin resistance in skeletal muscle that was associated with significantly elevated intramuscular fat content. In this study, we examined the effects of nob on obesity and insulin resistance, and the underlying mechanisms, in high fat diet hfd induced obese mice. Highfructose and highfat dietinduced insulin resistance. High fat diet will lead to hepatic steatosis and fatty liver changes could be obviously observed after dissection. It has been previously demonstrated that rats born sga due to intrauterine hypoxia, had increased propensity to develop diabetes when fed a hfd postnatally 18. Cytochrome p450 cyp2e1 knockout mice are protected. Research design and methods after 8 weeks on a high fat diet hfd, c57bl6j mice exhibited obesity, accompanied by insulin resistance and lowgrade chronic inflammation. Tfam enhances fat oxidation and attenuates highfat diet. Fatspecific sirt6 ablation sensitizes mice to highfat diet. Research design and methods after 8 weeks on a highfat diet hfd, c57bl6j mice exhibited obesity, accompanied by insulin resistance and lowgrade chronic inflammation. The aim of this study was to investigate the mechanism of pg suppressing the development of nafld induced by a highfat diet hfd in mice.
However, because the lowgrade inflammatory tone induced by high fat feeding initiates insulin resistance and glucose intolerance 2, 3 and because inflammatory cytokines are known to impair insulin signaling, the proinflammatory effect of estrogens should be considered as controversial. May 05, 2010 paradoxically, mice with an inherited deficiency of the mitochondrial fatty acid oxidation enzyme, very longchain acylcoa dehydrogenase vlcad, were protected from high fat diet induced obesity and liver and muscle insulin resistance. Cohorts of obese mice were continued on the hfd for an additional 8week treatment period with or without empagliflozin. Dimethylarginine dimethylaminohydrolase 1 protects against highfat dietinduced hepatic steatosis and insulin resistance in mice. Hup, mice were fed on a high fat diet supplemented with 5% ethanol extract from u. Empagliflozin reverses obesity and insulin resistance through. High fat diet induces central obesity, insulin resistance and. Helminthostachys zeylanica alleviates hepatic steatosis and. Pdf insulin resistance mediates highfat dietinduced. It has been suggested that skeletal muscle mitochondria play a key role in high fat hf diet induced insulin resistance ir. High fat diet induced insulin resistance and elevated retinol. Cohorts of obese mice were continued on the hfd for an additional 8. High fat diets hfd combine with genetic factors and other variables to reduce insulin sensitivity and promote the development of type 2 diabetes. Mup, serpinrelated, complement, and musclerelated gene families are also differentially expressed in terminal visceral tv adipose of mice with high or low hfdinduced insulin resistance.
Lup, mice were fed on a high fat diet supplemented with 2% ethanol extract from u. Combination of metformin and berberine represses the. Obesity has deleterious effects on the brain, and metabolic dysfunction may exacerbate the outcomes of seizures and brain injuries. A highfat, ketogenic diet causes hepatic insulin resistance.
However, its antidiabetic effect and molecular mechanisms are not yet fully understood. Supplementation of a highfat diet with chlorogenic acid is. Consumption of clarified grapefruit juice ameliorates high. Dietinduced insulin resistance ir adversely affects human health and life span. The present study investigated the effects of ethanol extract of u. However, the mechanism of pg against nonalcoholic fatty liver disease nafld is still not clear. Pdf acupuncture targeting sirt1 in the hypothalamic arcuate. Although insulin resistance has traditionally been associated with type 2 diabetes, mounting evidence indicates that the incidence of insulin resistance in type 1 diabetes is increasing. We report that older adults with insulin resistance show remarkably similar deficits in cognitive function and respond to glucose ingestion in a comparable manner to rodents fed a high fat diet, suggesting that insulin resistance is a probable mediator of these diet induced deficits.
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